Insomnia occurs in 18.6% of patients who take bupropion (Wellbutrin). Bupropion is a detoxification agent and an antidepressant. It regulates the brains in the amount of noradrenaline (norepinephrine), and dopamine. These endogenous substances involved in emotions and moods. Two percent of patients discontinue bupropion because of insomnia and agitation. Interestingly, 19.8% of patients experience sedation instead of insomnia. Decreasing the dose, adding a sedative drug or switching to a different antidepressant may alleviate the problem. For more information visit: Melatrol official website.